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美国麻省理工学院董婷博士做客学院“虞宏正论坛”

作者:         来源:         发布日期:2020-11-05     浏览次数:

     

报告题目: 天然产物分子探针揭示抗癌作用机制

报 告人: 董婷博士董.jpg

报告时间:2020年11月10日(星期二)下午4: 30

报告地点:理科大楼E 316

报告人简历:

tingdong@mit.edu, 617-785-7851

Koch Institute for Integrative Cancer Research  

Massachusetts Institute of Technology, Cambridge MA 02139

SCHOLARLY PROFILE

Biochemist with expertise in Chemistry, Chemical Biology, and Molecular Biology, especially proteomics and transgenic animals. Technical knowhow includes culture cells, notably stem cells, as well as western blot, qPCR, and FACS. Expertise developing novel chemical techniques such as bioorthogonal reactions for chemical biology research, and clarifying the mechanism of bio-active small molecules by using chemical genetic methods.


EDUCATION

2016 Ph.D. in Biochemistry and Molecular Biology

Peking Union Medical College, Beijing, China

Thesis: “Study towards Probe Guide-Natural Product Chemical Biology”

Thesis Advisor (biology part): Sudan He, Professor of Chemical Biology and Molecular Biology

2011 B.S. in Applied Chemistry

Northwest A&F University, Xianyang, China

RESEARCH EXPERIENCE

2016-2017 Postdoctoral Fellow, Department of Stem and Regenerative Biology, Harvard University, Cambridge, MA

2017-now Postdoctoral Fellow, Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology (MIT), Cambridge MA

HONORS AND PRIZES:

2008.10

National scholarship for undergraduate student;

First-class scholarship;

Merit student;

2009.10

National scholarship for undergraduate student;

First-class scholarship;

Merit student;

2010.10

National scholarship for undergraduate student;

First-class scholarship;

Merit student;

2011.06

Creative Student;

2013.10

Excellent Student;

2014.08

National scholarship for graduate student, NIBS Excellent Student.

Beijing outstanding doctoral graduate

PUBLICATIONS

1. Li Y, *Ivica N, * Ting Dong* (co-first author), Kleyman M, Hu G, Papageorgiou DP, He Y, Chen W, Sullivan LB. Del Rosario A, Hammond PT, Vander Heiden MG, Chen J. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme.  Nat Commun , 2020, 11(1): 4837. (IF:11.880)

2. Guangan Hu, Ting Dong, Sisi Wang, Hongyu Jing, Jianzhu Chen. Vitamin D3-Vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function.  EBioMedicine , 2019, Manuscript  Number: EBIOM-D-19-00986 (IF:6.680)

3. Xiaohui Liu, Ting Dong (co-first author), Yu Zhou, Niu Huang and Xiaoguang Lei*. Exploring the Binding Proteins of Glycolipids with Bifunctional Chemical Probes.  Angew. Chem. Int. Ed . 2016, 55, 14330. (IF:12.257)

4. Ting Dong,Chao Li,Xing Wang, Longyang Dian, Xiuguo Zhang, Lin Li, She Chen, Ran Cao, Li Li, Niu Huang, Sudan He* & Xiaoguang Lei*. Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine.  Nat.   commun.  2015,  6 , 6522. (IF:11.880)

5. Ting Dong, Weilong Liu, Zhirong Shen, Lin Li, She Chen & Xiaoguang Lei*. Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain.  Sci. Rep.  2016,  6 , 19231. (IF:4.525)

6. Ting Dong, Liao Daohong, Liu Xiaohui & Xiaoguang Lei*. Using Small Molecules to Dissect Non- apoptotic Programmed Cell Death: Necroptosis, Ferroptosis, and Pyroptosis.  ChemBioChem  2015,  16 , 2557.

7. Zhang Xiaoyun, Dong Ting (co-first author), Li Qiang, Xiaohui Liu, Xiaoying Yang & Xiaoguang Lei*. Second Generation TQ-Ligation for Cell Organelle Imaging.  ACS Chem. Biol.  2015,  10 , 1676. (IF:4.995)

8. Chao Li, Ting Dong (co-first author), Qiang Li & Xiaoguang Lei*. Probing the Anti-cancer Mechanism of (-)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation.  Angew. Chem. Int. Ed.  2014.  53 , 12111. (IF:12.257)

9. Qiang Li, Ting Dong (co-first author), Xiaohui Liu & Xiaoguang Lei*. A Bioorthogonal Ligation Enabled by Click Cycloaddition of  o ‑Quinolinone Quinone Methide and Vinyl Thioether.  J. Am. Chem. Soc.  2013,  135 , 4996. (News story describing this work was highlighted in  Chem. & Eng. News.  2013,  14 , 37.) (IF:14.695)

10. Qiang Li, Ting Dong, Xiaohui Liu, Xiaoyun Zhang & Xiaoguang Lei*.  ortho -Quinolinone Quinone Methide Finds its Applications in the Bioorthogonal Ligation.  Curr. Org. Chem.  2014,  18 , 86. (IF:2.157)

11. Chao Li, Ting Dong, Longyang Dian, Weidong Zhang & Xiaoguang Lei*. Biomimetic syntheses and structural elucidation of the apoptosis-inducing sesquiterpenoid trimers:(-)ainsliatrimers A and B.  Chem. Sci.  2013,  4 , 1163. (IF:9.556)

12. Ting Dong, Guang-Wei Wu, Xiao-Ning Wang, Jin-Ming Gao*, Jian-Guang Chen & Shoei-Sheng Lee. Microbiological transformationn of diosgenin by resting cells of filamentous fungus, Cunninghamella echinulata CGMCC 3.2716.  J.   Mol. Catal. B-enzym.  2010,  67 , 251. (IF:2.269)

Patents

1. Xiaoguang Lei, Chao Li, Ting Dong. Sesquiterpenoids, US patent, 20170044180, 02-06-2017.

PRESENTATIONS

MIT scholar meeting (2018)



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