一、个人简介
原田，女，汉族，生于1989年3月，中共党员，副教授，硕士生导师。研究方向为天然产物化学和化学生物学，主要从事天然植物化合物对于情绪障碍和认知障碍的改善作用及机制研究。
二、学习与工作经历
1.学习经历
(1) 2007-09 至 2011-06, 西北农林科技大学, 食品质量与安全, 学士
(2) 2011-09 至 2014-06, 西北农林科技大学, 粮食、油脂及植物蛋白工程, 硕士
(3) 2016-09 至 2019-06, 西北农林科技大学, 食品科学, 博士
2.工作经历
(1) 2014-06 至 2016-04, 西北农林科技大学, 测试中心, 实验员
(2) 2020-11 至 2022-12, 西北农林科技大学, 化学与药学院, 讲师
(3) 2023-01 至 今, 西北农林科技大学, 化学与药学院, 副教授
三、研究课题
(1) 国家自然科学基金委员会, 青年科学基金项目（C类）[原青年科学基金项目], 82103842, 基于肠道菌群/SCFAs/MUC2调控的芝麻酚缓解肠易激综合征中黏膜免疫激活及内脏超敏反应的作用机制研究, 2022-01-01至 2024-12-31, 资助期满, 主持
(2) 深圳市科技创新委员会, 省部级, JCYJ20220530161401004, 基于LXRABCA1ApoE调控的DHA对脑脂质代谢紊乱及认知功能障碍的影响及机制研究, 2022-10 至 2025-10, 在研, 主持
(3) 广东省科学技术厅, 省部级, 2021A1515110813, 基于SCFAs/MUC2调控的限制时间饮食缓解肠易激综合征中黏膜免疫激活失调的作用机制研究, 2021-10 至 2024-09, 资助期满, 主持
四、开设课程
为本科讲授《基础生物化学》和《无机及分析化学实验》。
五、主要科研成果与学术论文
(1) Tian Yuan; Chuanqi Chu; Rubing Shi; Tianlin Cui; Xinglin Zhang; Yihang Zhao; Xu Shi; Yan Hui; Junru Pan; Rui Qian; Xiaoshuang Dai; Zhigang Liu*; Xuebo Liu* ; ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the MicrobiomeGut-Brain Axis, Journal of Agricultural and Food Chemistry, 2019, 67(22): 6190-6201
(2) Zhigang Liu; Xiaoshuang Dai; Hongbo Zhang; Renjie Shi; Yan Hui; Xin Jin; Wentong Zhang; Luanfeng Wang; Qianxu Wang; Danna Wang; Jia Wang; Xintong Tan; Bo Ren; Xiaoning Liu; Tong Zhao;Jiamin Wang; Junru Pan; Tian Yuan; Chuanqi Chu; Lei Lan; Fei Yin; Enrique Cadenas; Lin Shi*; Shancen Zhao*; Xuebo Liu*; Gut Microbiota Mediates Intermittent-Fasting Alleviation of DiabetesInduced Cognitive Impairment, Nature Communications, 2020, 11(1): 855
(3) Qing Liu; Tianzhi Xie; Yujia Xi; Ling Li; Fengfeng Mo; Xuebo Liu; Zhigang Liu*; Jinming Gao; Tian Yuan* ; Sesamol Attenuates Amyloid Peptide Accumulation and Cognitive Deficits in APP/PS1 mice: The Mediating Role of the Gut-Brain Axis, Journal of Agricultural and Food Chemistry, 2021, 69(43): 12717-12729
(4) Duo Yun; Yajie Wang; Yuyu Zhang; Mengzhen Jia; Tianzhi Xie; Yihang Zhao; Cong Yang; Weixuan Chen; Rui Guo; Xuebo Liu; Xiaoshuang Dai; Zhigang Liu; Tian Yuan*; Sesamol Attenuates Scopolamine-Induced Cholinergic Disorders, Neuroinflammation, and Cognitive Deficits in Mice, Journal of Agricultural and Food Chemistry, 2022, 7(42): 13602-13614
(5) Yajie Wang; Yuyu Zhang; Xinyu Wang; Qingyuan Li; Yu Zhao; Yishan Jiang; Rui Guo; Xuebo Liu; Tian Yuan*; Zhigang Liu* ; Sesamol Mitigates Chronic Iron Overload‐Induced Cognitive Impairment and Systemic Inflammation via IL‐6 and DMT1 Regulation, Molecular Nutrition & Food Research, 2023, 67(17)
(6) Jiachen Ma, Tian Yuan, Yuqi Gao, Xiaoming Zeng, Zhigang Liu*, Jinming Gao*. Torreya grandis oil attenuates cognitive impairment in scopolamine-induced mice. Food & Function .2023 Nov 27;14(23):10520-10534.
(7) Xin Zhang, Tianzhi Xie, Shuang Zhou, Yingxuan Yuan, Weixuan Chen, Jie Zheng, Xuebo Liu, Tian Yuan *, Yanhui Lu *, Zhigang Liu *. Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids. Food & Function. 2024 Feb 19;15(4):2249-2264
(8) Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu*, Zhigang Liu*. Effects of DHA on cognitive dysfunction in aging and Alzheimer's disease: The mediating roles of ApoE. Progress in Lipid Research. 2024 Jan;93:101256
(9) Qianhui Zou, Shiyao Han, Jiarui Liang, Guiming Yan, Qianxu Wang, Yajie Wang, Zilong Zhang, Jun Hu, Jufang Li, Tian Yuan, Zhigang Liu*. Alleviating effect of vagus nerve cutting in Salmonella-induced gut infections and anxiety-like behavior via enhancing microbiota-derived GABA. Brain Behavior Immunity. 2024 Jul;119:607-620
(10) Qianxu Wang, Jiarui Liang, Qianhui Zou, Wenxiu Wang, Guiming Yan, Rui Guo, Tian Yuan, Yutang Wang*, Xuebo Liu, Zhigang Liu*. Tryptophan Metabolism-Regulating Probiotics Alleviate Hyperuricemia by Protecting the Gut Barrier Integrity and Enhancing Colonic Uric Acid Excretion. Journal of Agricultural and Food Chemistry. 2024 Dec 4;72(48):26746-26761.
六、联系方式
通讯地址：西北农林科技大学（北校区）化学与药学院
邮编：712100
邮箱：tian.yuan@nwafu.edu.cn
