一、个人简介
谢卫青，男，汉族，生于1979年3月，江西樟树人，三级教授，博士生导师，主要从事天然产物全合成研究工作。2015年作为青年英才引入西北农林科技大学，任教授、博士生导师。2017年获得自然科学基金优秀青年基金及陕西省“青年百人”资助，2018年获“ Thieme Chemistry Journals Award ”。截止目前在 Angew. Chem., Int. Ed.、ACS Catalysis.、Org. Lett.、 Org. Chem. Front.、 Chem. Commun. 等SCI收录的国际学术期刊上发表论文50余篇。
二、学习与工作经历
1.学习经历
1998.09-2002.07 兰州大学，有机化学专业，学士学位；
2002.09-2007.07 中科院上海有机化学研究所，有机化学专业，博士学位。
2.工作经历
2007.07-2009.09 中科院上海有机化学研究所，生命有机国家重点实验室工作，助理研究员；
2009.09-2011.08 美国达拉斯西南医学中心，从事博士后研究；
2011.08-2015.06 中科院上海有机化学研究所，生命有机国家重点实验室工作，副研究员；
2015.06-至今 西北农林科技大学，化学与药学院，教授。
三、研究课题
1. 国家自然科学基金面上基金（2024年-2027年，50万元）；
2. 国家自然科学基金面上基金（2022年-2025年，60万元）；
3. 国家自然科学基金优秀青年基金（2018年-2020年，130万元）；
4. 国家自然科学基金面上基金（2017年-2020年，65万元）；
5. 西北农林科技大学卓越人才计划（2016年-2019年，70万元）；
6. 西北农林科技大学人才启动经费（2015年-2019年，80万元）；
7. 国家自然科学基金面上基金（2014年-2017年，80万元）；
8. 国家自然科学基金青年基金（2013年-2015年，25万元）。
四、研究领域
1. 具有重要生理复杂活性天然产物的合成；
2. 目标导向合成方法学研究；
3. 基于天然产物的化学生物学研究。
五、开设课程
为本科生讲授《《有机合成进展》、《有机合成综合训练》，为研究生讲授《药学前沿讲座》
六、主要科研成果与学术论文
1. Construction of contiguous quaternary carbon centers enabled by dearomatization of phenols with 3-bromooxindoles. Hui Li,‡ Xi Wang,‡ Minhang Chang, Mengbo Wu, Xinyu Yuan, Xiangyu Hui, Hongbo Wei, * Juyun Xi* and Weiqing Xie* , Org. Biomol. Chem. , 2024, 22, 8413-8417.
2. Synthetic Modification and Insecticidal Activity of 4-epi-cis-Dihydroagarofuran Derivatives. Ziyu Wang, Wei Jiang, Rong Tang, Hongxiang Liu, Hao Qian, Tao Guo, Jianjun Zhu, Wenjun Wu, Weiqing Xie*, Jiwen Zhang*, J. Agric. Food Chem. 2024, 72, 15552–15560.
3. A novel approach to the tetracyclic frameworks of anislactone-type sesquiterpenoids. Long He,‡ Xiaocheng Zhang,‡ Sen Li, Xuexue Tian, Yimeng Han, Haitao Xie* and Weiqing Xie*, Org. Chem. Front ., 2024, 11, 4556-4559.
4. A de novo synthesis of the bisindole alkaloid geissolosimine: collective synthesis of geissoschizoline, akuammicine, (16S)-deshydroxymethylstemmadenine and Aspidospermatan alkaloids. Jiahang Yan,‡Yanxia Zhen,‡ Pengyan Wang,‡ Yimeng Han, Huanhuan Zou, Junhan Chen, Weigang He* and Weiqing Xie*, Org. Chem. Front. , 2024, 11, 4556–4559.
4. Gram-scale synthesis of alstoscholarinoid B via a bio-inspired strategy. Long He,‡ Wenting Zhang,‡ Xiaocheng Zhang,‡ Xiaohui Wu, Yimeng Han, Jiahang Yan* and Weiqing Xie*, Org. Biomol. Chem. 2023, 21, 9346-9355
5. Asymmetric Synthesis of (+)-Vellosimine Enabled by a Sequential Nucleophilic Addition/Cyclization Process. Huanhuan Zou, Jiahang Yan*, Xiaocheng Zhang, Xiaohui Wu, Jiyou Huo, Yuanzhen Xu*, and Weiqing Xie*, Org. Lett. , 2023, 25, 8215–8219.
6. Stereodivergent Construction of Contiguous Quaternary Carbon Centers Enabled by Asymmetric Catalysis. Jiyou Huo, Xiuhuan Li, Qianhu Chen, Pengpeng Gao, Yi Hou, Pan Lei, Huanhuan Zou, Jiahang Yan*, Xiaolong Wan*, and Weiqing Xie*, ACS Catalysis. , 2023, 13, 15007-15012.
7. Catalytic Asymmetric Reverse Prenylation of Indol-2-one Enabled a Synthesis of (−)-Debromoflustramine A. Yi Hou, Jiyou Huo, Ruoxin Li, Jun Hou, Pan Lei, Hongbo Wei*, and Weiqing Xie*, Org. Lett. 2023, 25, 6949–6953.
8. A formal synthesis of (–)-erinacine B enabled by asymmetric organocatalysis. Jiahang Yan,‡ Dongyang Xu,‡ Zhiqiang Zhou,‡ Long He, Jin-Ming Gao,* Hongbo Wei* and Weiqing Xie*, Chem. Commun. , 2023, 59, 7092-7095.
9. Catalytic Asymmetric Friedel–Crafts Alkylation of Indole via In Situ Generated Indol-2-one. Yuanai Fei, Jun Hou, Huiying Song, Mei-li Yang, Pan Lei, Xiayu Ge, Hongbo Wei*, Yuanzhen Xu*, Weiqing Xie*, Eur. J. Org. Chem. 2023, 26, e202300122.
10. Catalytic asymmetric construction of C2-symmetric contiguous quaternary carbon centers enabled a concise synthesis of (−)-chimonanthidine and (−)-folicanthine. Yuanzhen Xu, Pan Lei, Yuannai Fei, Yi Hou, Guzhou Chen, Zhiqiang Zhou, Huanhuan Zou, Hongbo Wei* and Weiqing Xie*, Tetrahedron Lett. , 2023, 114, 154261.
11. Convergent Synthesis of Enantioenriched ortho-Fused Tricyclic Diketones via Catalytic Asymmetric Intramolecular Vinylogous Aldol Condensation. Zhiqiang Zhou, Dongyang Xu, Wei Jiang, Junhan Chen, Yanxia Zhen, Jiyou Huo, Jiahang Yan*, Jinming Gao* and Weiqing Xie*, Org. Lett. 2022, 24, 49, 9017-9022.
12. Enantioselective direct vinylogous Michael addition for constructing enantioenriched γ,γ-dialkyl substituted butyrolactams and octahydroindoles. Jiahang Yan, Wenting Zhang, Qiaoqiao He, Jun Hou, Hongxin Zeng, Hongbo Wei* and Weiqing Xie*, Org. Biomol. Chem. , 2022, 20, 2387-2391.
13. A concise synthesis of herbertenolide. Jiadong Hu, Kai Ji, Lihong Yan, Siyu Yang, Yin Li, Wen Wen, Le Chen, Xiaohui Wu, Youcai Hu and Weiqing Xie*, Org. Biomol. Chem. , 2022, 20, 2205-2208.
14. The applications of catalytic asymmetric halocyclization in natural product synthesis. Jiahang Yan, Zhiqiang Zhou, Qiaoqiao He, Guzhou Chen, Hongbo Wei * and Weiqing Xie*, Org. Chem. Front. , 2022, 9, 499-516.
15. 2,2,2-Trifluroenthanol promoted synthesis of unsymmetrical ureas from dioxazolones and amines via tandem lossen rearrangement/condensation process, Jian Li, Wang He, Pan Lei, Jiacheng Song, Jiyou Huo, Hongbo Wei* Hongjin Bai* and Weiqing Xie*, Synth. Commun. , 2021, 51(23): 3590-3600.
16. A Concise Synthesis of (-)-Dihydrospirotryprostatin B via Tandem Michael Addition. Hengqian Song, Jiacheng Song, Lihong Yan, Weigang He, Pengyan Wang, Yuanzhen Xu, Hongbo Wei,* Weiqing Xie*, Tetrahedron Lett. 2021, 85, 153486-153489.
17. An Asymmetric Synthesis of (+)-Isostrychnine Based on CatalyticAsymmetric Tandem Double Michael Addition. Pengyan Wang, Junhan Chen, Weigang He, Jiacheng Song, Hengqian Song, Hongbo Wei*, and Weiqing Xie* Org. Lett. 2021, 23, 5476–5479
18. The catalytic asymmetric dearomatization of tryptamine for accessing meso-contiguous quaternary carbon centers of oligomeric cyclotryptamine alkaloids: a formal synthesis of hodgkinsine B. Hongbo Wei, Guzhou Chen, Huanhuan Zou, Zhiqiang Zhou, Pan Lei, Jiahang Yan and Weiqing Xie*. Org. Chem. Front. , 2021, 8, 3255-3259.
19. Au(I)-Catalyzed Domino Cyclization of 1,6-Diynes Incorporated with Indole. Guzhou Chen, Peng-Yu Liu, Huanhuan Zou, Jiadong Hu, Xiaowu Fang, Dongyang Xu, Yu-Peng He*, Hongbo Wei*, and Weiqing Xie*. Org. Lett. 2021, 23, 2279–2284.
20. Asymmetric Synthesis of ent-Fissistigmatin C. Dongyang Xu, Jiadong Hu, Le Chen, Lu Chen, Jiang Su, Jinjin Yang, Siyu Deng, Hongli Zhang* and Weiqing Xie*. Org. Lett. 2021, 23, 93–96.
21. Asymmetricsynthesis of 9-alkyl tetrahydroxanthenones via tandem asymmetric Michael/cyclization promoted by chiral phosphoric acid. Yu-Qi Gao, Yi Hou, Junhan Chen, Yanxia Zhen, Dongyang Xu, Hongli Zhang, Hongbo Wei and Weiqing Xie*. Org. Biomol. Chem. , 2021, 19, 348–354.
22. Highly enantioselective addition of aliphatic aldehydes to 2-hydroxychalcone enabled by cooperative organocatalysts, Jiadong Hu+, Yu Qi Gao+, Dongyang Xu, Le Chen, Wen Wen, Yi Hou, Lu Chen and Weiqing Xie*. Chem. Commun. , 2020, 56, 10018-10021.
23. Advances in the Synthesis of Anislactone-type Sesquiterpenes. Jian Li, Long He, Zhiqiang Zhou, Yanxia Zhen, Weiqing Xie.Chin. J. Org. Chem. , 2020, 40, 3166-3176.
24. Visible-light driven synthesis of polycyclic benzo[d][1,3]oxazocine from 2-aminochalcone. Yu-Qi Gao, Yi Hou, Liming Zhu, Junhan Chen, Ruoxin Li, Sheng-Yong Zhang,* Yu-Peng He* and Weiqing Xie*. Chem. Commun. , 2020, 56, 6739-6742.
25. Recent progress in the total synthesis of Strychnos alkaloids. Weigang He, Pengyan Wang, Junhan Chen, Weiqing Xie*. Org. Biomol. Chem. , 2020, 18, 1046–1056.
26. A bio-inspired synthesis of hybrid flavonoids from 2-hydroxychalcone driven by visible light. Yu-Qi Gao, Yi Hou, Liming Zhu, Guzhou Chen, Dongyang Xu, Sheng-Yong Zhang, Yupeng He, Weiqing Xie*. RSC Advances , 2019, 9, 29005-29009.
27. Concise syntheses of (+)-austrodoral and (+)-austrodoric acid Based on H2O2 mediated oxidative ring contraction. Hongbo Wei, Hongli Zhang, Shoule Han, Shan Mu, Ke Huang, Guzhou Chen, Weiqing Xie*. Tetrahedron Letters , 2019, 60, 150973.
28. Carboxylate phosphabetaine as a bifunctional organocatalyst for the intramolecular ring opening of oxetane. Dongyang Xu,‡ Hongbo Wei,‡ Yanxia Zhen, Yu-Qi Gao, Ruoxin Li, Xingzhou Li, Yupeng He, Zhong Zhang and Weiqing Xie*. Org. Chem. Front. , 2019, 6, 1681-1685.
29. Highly Enantioselective Tandem Michael Addition of Tryptamine-Derived Oxindoles to Alkynones: Concise Synthesis of Strychnos Alkaloids. Weigang He,† Jiadong Hu,† Pengyan Wang,† Le Chen, Kai Ji, Siyu Yang, Yin Li, Zhilong Xie and Weiqing Xie*. Angew. Chem. Int. Ed. , 2018, 57, 3806-3809.
30. New Strategy for Forging Contiguous Quaternary Carbon Centers via H2O2-Mediated Ring Contraction. Jiadong Hu, Xin Yu, Weiqing Xie*. Synlett 2017; 28, 2517-2524.
31. Facile Access to 2,2-Disubstituted Indolin-3-ones via Cascade Fischer Indolization/Claisen Rearrangement Reaction. Zilei Xia, Jiadong Hu, Yu-Qi Gao, Qizheng Yao* and Weiqing Xie*. Chem. Commun. 2017, 53, 7485-7488.
32. A Re2O7 catalyzed cycloetherification of monoallylic diols. Xiaolong Wan+, Jiadong Hu+, Dongyang Xu, Yang Shang, Yanxia Zhen, Chenchen Hu, Fan Xiao, Yu-Peng He*, Yisheng Lai*, Weiqing Xie*. Tetrahedron Lett. , 2017, 58, 1090-1093.
33. Stereospecific Construction of Contiguous Quaternary All-Carbon Centers by Oxidative Ring Contraction. Xin Yu+, Jiadong Hu+, Zhigao Shen, Hui Zhang, Jin-Ming Gao, and Weiqing Xie*. Angew. Chem. Int. Ed. , 2017, 56, 350-353.
34. Tandem allylic alcohol isomerization/oxo-Michael addition reaction promoted by Re2O7. Jiadong Hu, Dongyang Xu, Qiang Zhang, Yang Shang, Mumin Shi, Yucui Huangfu, Leilei Liu, Rong liang, Yisheng Lai,* Yupeng He,* Jin-ming Gao and Weiqing Xie*. RSC Advances 2016, 6, 52583-52586.
35. Enantioselective Bromo-oxycyclization of Silanol, Zilei Xia, Jiadong Hu, Zhigao Shen, Xiaolong Wan, Qizheng Yao, Yisheng Lai, Jin-Ming Gao, Weiqing Xie*, Org. Lett. , 2016, 18, 80–83.
36. Chiral Ion-Pair Organocatalyst Promotes Highly Enantioselective 3-exo Iodo-cycloetherification of Allyl Alcohols, Zhigao Shen, Xixian Pan, Yisheng Lai, Jiadong Hu, Xiaolong Wan, Xiaoge Li, Hui Zhang, Weiqing Xie*, Chem. Sci. , 2015, 6, 6986-6990.
37. Total Synthesis of (-)-Conolutinine. Xiangyang Feng, Guangde Jiang, Zilei Xia, Jiadong Hu, Xiaolong Wan, Jin-Ming Gao, Yisheng Lai*, Weiqing Xie*, Org. Lett. , 2015, 17, 4428–4431.
38. Synthesis of Naked Amino-Pyrroloindoline via Direct Aminocyclization of Tryptamine,Zhigao Shen, Zilei Xia, Huijun Zhao, Jiadong Hu, Xiaolong Wan, Yisheng Lai,* Chen Zhu*, Weiqing Xie*, Org. Biomol. Chem. , 2015, 13, 5381-5384.
39. Re2O7 catalyzed dienone-phenol rearrangement, Zilei Xia+, Jiadong Hu+, Zhigao Shen, Qizheng Yao*, Weiqing Xie*, RSC Adv. , 2015, 5, 38499-38502.
40. Oxidative Rearrangement of Malondialdehyde: Substrate Scope and Mechanistic Insights, Xin Yu, Zheng Liu, Zilei Xia, Zhigao Shen, Xixian Pan, Hui Zhang* and Weiqing Xie*, RSC Adv. , 2014, 4, 53397-53401.
41. Decarboxylative Hydroamination of Propiolic Acids with N-Heterocycles under Transition-Metal-Free Condition, Xixian Pan, Hui Zhang,* Xin Yu, Xiaolong Wan, Weiqing Xie*, Synlett. 2014, 46, 2057-2064.
42. Highly Asymmetric Bromocyclization of Tryptophol: Unexpected Accelerating Effect of DABCO-derived Bromine Complex, Huan Liu, Guangde Jiang, Xixian Pan, Xiaolong Wan, Yisheng Lai,*, Dawei Ma* and Weiqing Xie*, Org. Lett. 2014, 16, 1908–1911.
43. Highly Enantioselective Bromocyclization of Tryptamines and Its Application in the Synthesis of (-)-Chimonanthine, Weiqing Xie*, Guangde Jiang, Huan Liu, Jiadong Hu, Xixian Pan, Hui Zhang, Xiaolong Wan, Yisheng Lai*, Dawei Ma*, Angew. Chem. Int. Ed. 2013, 52, 12924-12927.
44. Diastereoselective Construction of Continuous All-Carbon Quaternary Centers via Intramolecular Oxidative Coupling Reaction, Weiqing Xie*, Hexiang Wang, Feng Fan, Junshan Tian, Zhiwei Zuo, Weiwei Zi, Kun Gao*, Dawei Ma*, Tetrhedron Lett. 2013, 54, 4392-4396.
45. Intramolecular Oxidative Coupling: Applications in Synthesis of Complex Indole Akaloid Scaffolds, Zhiwei Zuo, Weiwei Zi, Weiqing Xie*, Dawei Ma*, Chin. J. Org. Chem. 2013, 33, 869-876.
46. Asymmetric, Regioselective Bromohydroxylation of 2-Aryl-2-propen-1-ols Catalyzed by Quinine-Derived Catalysts, Ye Zhang, Hui Xing, Weiqing Xie*, Xiaolong Wan, Yisheng Lai*, Dawei Ma*, Adv. Synth. Catal. 2013, 355, 68–72.
47. Cascade annulation of malonic diamides: a concise synthesis of polycyclic pyrroloindolines, Feng Fan, Weiqing Xie*, Dawei Ma*, Chem. Commun. , 2012, 48, 7571–7573.
48. Total Synthesis of Akuammiline Alkaloid (−)-Vincorine via Intramolecular Oxidative Coupling, Weiwei Zi, Weiqing Xie, Dawei Ma*, J. Am. Chem. Soc. , 2012, 132, 9126−9129.
49. Construction of Polycyclic Spiroindolines via an Intramolecular Oxidative Coupling/Cyclization Cascade Reaction Process, Feng Fan, Weiqing Xie*, Dawei Ma*, Org. Lett. 2012, 14, 1405–1407.
七、联系方式
通讯地址：西北农林科技大学（北校区）化学与药学院（C306）
邮编：712100
邮箱：xiewq@nwafu.edu.cn; xiewqsioc@aliyun.com
课题组主页：http://www.groupxie.com/
