一、个人简介
翟怡杰，女，汉族，生于1995年10月，陕西西安人，中共党员，副教授。主要从事微生物活性天然产物发现及合成生物学研究，研究成果先后发表在Angew. Chem. Int. Ed.、J. Agric. Food Chem.、Org. Chem. Front.、J. Nat. Prod.等SCI期刊上，主持国家自然科学基金青年项目。
二、学习与工作经历
1.学习经历
2013.09-2017.06，西北农林科技大学，生物技术，学士学位
2017.09-2022.06，西北农林科技大学，化学生物学，博士学位
2.工作经历
2022.07-2025.06，西北农林科技大学，植物保护学流动站，博士后
2025.07-至今，西北农林科技大学，化学与药学院，副教授
三、研究课题
1. 国家自然科学基金青年项目，主持，苔藓内生真菌SQ11-20双功能抗骨质疏松先导发现及作用机制研究，2025.01-2027.12，30万元
2. 国家自然科学基金面上项目，参与，具有基于基因组信息的鼠妇共生真菌SF09代谢产物多样性的挖掘及神经营养和保护功能研究，2021.01-2025.12，55万元
3.陕西省创新能力支撑计划项目，参与，2024.01-2026.12，50万
四、研究领域
1.特境真菌活性天然产物的发现及生物功能研究
2.重要生物活性天然产物的作用靶点及机制研究
3.结构复杂天然产物的生物合成及酶学机制解析
五、开设课程
《大学化学》、《无机分析化学》、《天然产物化学》等
六、主要科研成果与学术论文
1. Wen-Bo Han,*# Yi-Jie Zhai#, Rong Zhang, Xu-Shun Gong, Jia-Qian Li, Gong Xu,* Xinxiang Lei, Liangcheng Du, and Jin-Ming Gao.* Tricrilactones A–H, Potent Antiosteoporosis Macrolides with Distinctive Ring Skeletons from Trichocladium crispatum, an Alpine Moss-Associated Fungus. Angew. Chem. Int. Ed. 2023, 62, e202300773.
2. Yi-Jie Zhai, Zhen-Zhen Zhou, Lin-Lin Gao, Jian-Nan Li, Gennaro Pescitelli,* Jin-Ming Gao, and Wen-Bo Han.* Ethylidene-Tethered Chromene-Pyrone Hybrids as Potential Plant Growth Regulators from an Endolichenic Phaeosphaeria Specie. J. Agric. Food Chem. 2023, 71, 4615−4624.
3. Yi-Jie Zhai#, Zhen-Zhen Zhou#, Wen-Ji Wang, Xin-Yu Wang, Zi-Jue Wang, Guang-Zhi Dai, Xinxiang Lei, Wen-Li Li, Jin-Ming Gao*, Wen-Bo Han.* Herpotriquinones A and B, two dimeric naphthoquinone–epoxycyclohexenone adducts with anti-neuroinflammatory activity from the isopod-associated fungus Herpotrichia sp. SF09. Org. Chem. Front. 2024, 11, 6069−6077.
4. Wen Bo Han#, Yi Jie Zhai#, Yuqi Gao, Hui-Yi Zhou, Jian Xiao, Gennaro Pescitelli, and Jin Ming Gao.* Cytochalasins and an Abietane-Type Diterpenoid with Allelopathic Activities from the Endophytic Fungus Xylaria Species. J. Agric. Food Chem. 2019, 67, 3643−3650.
5. Yi-Jie Zhai, Guang-Ming Huo#, Qiang Zhang, Ding Li, Da-Cheng Wang, Jian-Zhao Qi, Wen-Bo Han,* and Jin-Ming Gao.* Phaeosphaones: Tyrosinase Inhibitory Thiodiketopiperazines from an Endophytic Fungus Phaeosphaeria fuckelii. J. Nat. Prod. 2020, 83, 1592−1597.
6. Yi-Jie Zhai, Guang-Ming Huo#, Jing Wei, Li-Bin Lin, Qiang Zhang, Jian-Nan Li, Xin Chen, Wen-Bo Han,* Jin-Ming Gao.* Structures and absolute configurations of butenolide derivatives from the isopod-associated fungus Pidoplitchkoviella terricola. Phytochemistry 2022, 193, 112981.
7. Yi-Jie Zhai, Shu-Hui Zhao, Jin-Ming Gao, Wen-Bo Han. Cytochalasins and orsellinic acid derivatives with cytotoxicity from the soil-derived fungus Trichocladium asperum. Phytochemistry. 2024, 231, 114340.
8. Yi Jie Zhai, Jian Nan Li, Yu Qi Gao, Lin Lin Gao, Da Cheng Wang, Wen Bo Han,* Jin Ming Gao.* Structurally Diverse Sesquiterpenoids with Anti neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae. Natural Products and Bioprospecting, 2021,11, 325−332.
9. Xiao-Qi Duan，Xin-Yu Wang，HuaiChang Qi，Yi-Jie Zhai*，Wen-Bo Han.* Neuroprotective indole alkaloids from the soil-derived fungus Trichocladium sp. XZ8. J. Nat. Prod. 2025, 88(1):175−182.
七、联系方式
通讯地址：西北农林科技大学（北校区）化学与药学院
邮编：712100
